Bioinformatics: Sequence Alignment and Markov Models

Product Description

GET FULLY UP-TO-DATE ON BIOINFORMATICS-THE TECHNOLOGY OF THE 21ST CENTURY

Bioinformatics showcases the latest developments in the field along with all the foundational information you’ll need. It provides in-depth coverage of a wide range of autoimmune disorders and detailed analyses of suffix trees, plus late-breaking advances regarding biochips and genomes.

Featuring helpful gene-finding algorithms, Bioinformatics offers key information on sequence alignment, HMMs, HMM applications, protein secondary structure, microarray techniques, and drug discovery and development. Helpful diagrams accompany mathematical equations throughout, and exercises appear at the end of each chapter to facilitate self-evaluation.

This thorough, up-to-date resource features:

• Worked-out problems illustrating concepts and models
• End-of-chapter exercises for self-evaluation
• Material based on student feedback
• Illustrations that clarify difficult math problems
• A list of bioinformatics-related websites

Bioinformatics covers:

• Sequence representation and alignment
• Hidden Markov models
• Applications of HMMs
• Gene finding
• Protein secondary structure prediction
• Microarray techniques
• Drug discovery and development
• Internet resources and public domain databases

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Job Posting – Systems and Algorithms Engineer at DNA startup – Palo Alto, CA

Does building great things run in your DNA?

DNAnexus is a start-up in biocomputation aiming to transform the future of genomic analysis. The rapid advancement of DNA sequencing technologies will one day enable one of the holy grails of medicine: the personal genome. But it is also unleashing a torrent of data that needs to be managed and analyzed. DNAnexus is leveraging modern web technologies on a cloud computing infrastructure to create a compute platform for the genome era. We are backed by a collection of leading investors, including early-stage VC First Round Capital.

DNAnexus comprises a team of individuals that include MIT alumni, Stanford PhDs in computational genomics, and Professors in Computer Science, Genetics, and Pathology, and we’re passionate about changing the future of DNA analysis and genetics.

Interested in joining in our effort? We’re currently looking for individuals that fit the following profiles:

Systems and Algorithms Genius

DNAnexus is recruiting an exceptional developer to join the team in designing and implementing methods for large scale analysis of DNA sequence data. The ideal candidate would be extremely strong in building complex models for deciphering noisy datasets, and be comfortable with the idea of channeling Petabytes of data and distributing workloads onto 1000s of machines. Also, the following should resonate with you:

- You are fluent in C/C++ and understand the implications of your coding style down to the level of machine code.
- You are comfortable with distributed systems, from consistency and synchronization in multi-threaded applications to concurrent database design, cluster computing, and distributed file systems.
- You could write your own generic balanced binary trees and suffix trees. Dynamic programming and divide and conquer come easily to you. You understand the intricacies of dynamic hash table design.
- You have practical experience with Bayesian modeling and inference, machine learning, statistics, and optimization.

A background in bioinformatics or DNA sequence analysis is a plus, not a necessity, but you must be comfortable learning a new domain quickly. If you enjoy working in a fast-moving startup environment and want to apply your talent to an area of great significance, DNAnexus is for you!

Location: Palo Alto, CA
More info: http://dnanexus.com/careers